Beilstein J. Org. Chem.2010,6, No. 21, doi:10.3762/bjoc.6.21
related β-galactosidase mutants.
Keywords: chemical chaperones; 1-deoxy-D-galactonojirimycin; iminosugars; lipophilic galactosidase inhibitor; N-modifiediminosugars; Introduction
Iminosugars such as compounds 1–4 (Figure 1) have been shown to be potent glycosidase inhibitors and useful tools for the
currently in progress.
Typical representatives of iminosugars.
N-Modifiediminosugars 5–9 as potential pharmacological chaperones.
Structure of NOEV 10.
Three-step-synthesis of partially protected 1-deoxy-D-galactonojirimycin derivative 12 from 10 via L-arabino-hexos-5-ulose 11.
Synthesis of N-(6-aminohexyl